04 August 2011

Hiv Aids Disease Treatment

Although HIV is an incurable disease till date, various medications facilities are available which can help conditions from getting worse and delay the arrival of AIDS. With the help of theses medications an HIV infected person can lead a fairly normal life for a considerably longer period of time. HIV medication helps in preventing the virus from spreading further for a considerably long time. It tries to stop the virus from growing further, as well as stopping it from infecting the unaffected cells.

It is to be known here that HIV belongs to a unique class of viruses which are not composed of DNA, but is composed of RNA. As such HIV medication can be broadly classified under the following categories:

1. Reverse transcriptase (RT) inhibitors
An important aspect, which makes HIV so much dangerous, is its genetic variability. As discussed earlier, HIV is composed of RNA. However, once the virus enters the body of an individual, it replicates itself into HIV DNA, with the help of Reverse Transcriptase, which is an HIV enzyme. To tackle this problem, RT inhibitors play a very important role. There are basically two main types of RT inhibitors.

(a) Nucleoside/nucleotide RT inhibitors are basically variants of DNA blocks, which enter the HIV DNA, while the RT is at work; and stop the HIV DNA chain from completion. This acts as a major inhibitor for the HIV from replicating itself; while the Nucleoside/nucleotide RT inhibitors are increasing your CD4 cell count. Examples of Nucleoside/nucleotide RT inhibitors are Azidothymidine, zalcitabine and dideoxyinosine.

(b) Non-nucleoside RT inhibitors  work in the same direction, by binding itself to RT and stopping the HIV RNA from converting itself into HIV DNA. Examples include Delavridine (Rescriptor) and Nevirapine (Viramune).

2. Protease inhibitors 
Protease inhibitors basically perform the function of dealing with the protease enzyme, which is used by the HIV for developing infectious viral particles. The most common drug in this category is Ritonavir (Norvir).

3. Entry and fusion inhibitors
Entry and fusion inhibitors are used for dealing with the ability of HIV to fuse into the cellular membrane, which helps in stopping it from entering into the host cell. An example of this category is Fuzeon.

4. Integrase inhibitors Integrase inhibitors are used for dealing with integrase, which is an enzyme used by HIV for incorporating its genetic material into its target host cell.

5. Multidrug combination products Apart from the above medication procedures, we also have the Multidrug combination products, which combine drugs from two or more categories to form a single medical category. This is because, HIV is a virus with high genetic variability and so, variants of it emerge quite easily, which are resistant to antiretroviral drugs. To deal with this multi drug combination products are used.

It is to be noted here that a patient may suffer from side effects arising from the use of these drugs, which may differ from person to person. Therefore, a patient undergoing treatment should be prepared for it. However, it is a very small charge, in comparison to what it actually gives you.

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